The Metabolomics and Analytics Centre (MAC) at the Leiden Academic Centre of Drug Research at Leiden University will conduct metabolomics and lipidomics measurements of blood samples to develop metabolic and lipidomic biomarkers to diagnose MALSD and MASH.
For the metabolomics and lipidomics MAC is using innovative technologies combined with advanced mass spectrometric methods, and using automated sample preparation and robotics. MAC is miniaturizing the analytical methods to analyse liver-derived extracellular vesicles and samples obtained from the organ-on-a-chip model, even down to individual cells.